Article
Blending and separating dynamics of RNA-binding proteins develop architectural splicing networks spreading throughout the nucleus.
Molecular cell - 8 Aug 2024
Masuda Akio, Okamoto Takaaki, Kawachi Toshihiko, Takeda Jun-Ichi, Hamaguchi Tomonari, Ohno Kinji
Abstract excerpt
The eukaryotic nucleus has a highly organized structure. Although the spatiotemporal arrangement of spliceosomes on nascent RNA drives splicing, the nuclear architecture that directly supports this process remains unclear. Here, we show that RNA-binding proteins (RBPs) assembled on RNA form meshworks in human and mouse cells. Core and accessory RBPs in RNA splicing make two distinct meshworks adjacently but...
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