Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-Cell Genetic Mapping of Gasdermin Expression Across Immune-Mediated Inflammatory Diseases.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 15 Jan 2026

Gao Xin, Guo Xiaofeng, Yin Kaige, Jin Xiaoxu

Abstract excerpt

The gasdermin (GSDM) family mediates pyroptosis and membrane pore formation, but the causal, cell-type-specific roles of individual paralogues in immune-mediated inflammatory diseases (IMIDs) remain poorly defined. We combined single-cell cis-eQTL data from 14 peripheral blood immune subsets (OneK1K) with genome-wide association data from FinnGen release 12 to perform lineage-resolved Mendelian randomization (MR)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to GSDMB gene
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inflammation

Share to Mendelian Randomization Analysis

Share to Neoplasm Proteins

Share to Phosphate-Binding Proteins

Share to Polymorphism, Single Nucleotide

Share to Single-Cell Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 41442179
DOI: 10.1096/fj.202503059RR
PMCID: PMC12733618

Genes

GSDMB
GSDMA
GSDMD
CD4
GSDMC
GSDME

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-Cell Genetic Mapping of Gasdermin Expression Across Immune-Mediated Inflammatory Diseases.PMID 41442179Read ↗

Integration of single-cell transcriptome and genetic profiles reveals critical cell types and genes in inflammatory bowel diseaseSemantic proximity Read ↗

Cell-type-resolved genetic regulatory variation shapes inflammatory bowel disease riskSemantic proximity Read ↗

Cell-type-resolved genetic variation shapes inflammatory bowel disease risk.Semantic proximity Read ↗

Integrating Mendelian randomization and multiple-trait colocalization to uncover cell-specific inflammatory drivers of autoimmune and atopic diseaseSemantic proximity Read ↗

Cross-trait mapping of shared susceptibility across inflammatory bowel disease and spondyloarthropathies.Semantic proximity Read ↗

Multivariable genome-wide analysis elucidates the shared genetic architecture, immunosenescence features, and gut-origin therapeutic targets of ulcerative colitis-associated multisystem inflammation.Semantic proximity Read ↗

Single-cell genetics identifies cell-type-specific effector genes across complex traits and diseasesSemantic proximity Read ↗

An Integrated Taxonomy for Monogenic Inflammatory Bowel Disease.Semantic proximity Read ↗

An atlas of the shared genetic architecture between atopic and gastrointestinal diseases.Semantic proximity Read ↗

Spatial genetic mapping links shared inflammatory bowel disease liability to adult immune-epithelial lesion contexts.Semantic proximity Read ↗

Cross-phenotype genome-wide association study supports shared genetic etiology between skin and gastrointestinal tract diseasesSemantic proximity Read ↗

Genome‐Wide Aggregated Trans Effects Analysis Identifies Genes Encoding Immune Checkpoints as Core Genes for Rheumatoid ArthritisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.