Article
Multivariable genome-wide analysis elucidates the shared genetic architecture, immunosenescence features, and gut-origin therapeutic targets of ulcerative colitis-associated multisystem inflammation.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] - 7 May 2026
Tang Shanneng, Yao Xin, Wang Shanshan, Zhu Fanfan, Zeng Wenbin, Lai Dongping, Meng Xiaobing, Zhang Xinyue, Zhu Ziming, Zhang Tao, Xu Ri'an
Abstract excerpt
BACKGROUND: Over 25% of patients with ulcerative colitis (UC) develop extraintestinal manifestations (EIMs), resulting in significant systemic morbidity. We define the shared genetic foundation of these manifestations as the UC-associated Multisystem Inflammatory Genetic Architecture (UC-MIGA). This study aims to identify shared genomic drivers and actionable immunosenescence therapeutic targets across the UC-EIM...
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