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Article

Genome-Wide Aggregated Trans Effects Analysis Identifies Genes Encoding Immune Checkpoints as Core Genes for Rheumatoid Arthritis.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Jul 2025

Spiliopoulou Athina, Iakovliev Andrii, Plant Darren, Sutcliffe Megan, Sharma Seema, Cubuk Cankut, Lewis Myles, Pitzalis Costantino, Barton Anne, McKeigue Paul M

Abstract excerpt

OBJECTIVE: The sparse effector "omnigenic" hypothesis postulates that the polygenic effects of common single nucleotide polymorphisms (SNPs) on a typical complex trait are mediated by trans effects that coalesce on expression of a relatively sparse set of core genes. The objective of this study was to identify core genes for rheumatoid arthritis by testing for association of rheumatoid arthritis with genome-wide...

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Source

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Identifiers

PMID: 39887658
DOI: 10.1002/art.43125
PMCID: PMC12209750

Genes

PDCD1
CTLA4
LAIR1
TNFRSF14
CD5
IDO1
LILRA4
TIGIT
TP53BP1

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