Article

Single-cell genetics identifies cell-type-specific effector genes across complex traits and diseases

2025-08-29

Abstract excerpt

Genome-wide association studies (GWAS) have been instrumental in uncovering the genetic basis of complex traits. When integrated with expression quantitative trait loci (eQTL) mapping, they can help identify effector genes within GWAS loci through gene regulatory mechanisms. Recent single-cell eQTL (sc-eQTL) studies suggest that genetic effects on gene expression are often cell type- and subtype-specific, providin...

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Literature Corpus work: ab5fd916-e1d1-5db5-a329-9ebb461dcbdc
DOI: 10.1101/2025.08.28.25334614

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