Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cross-phenotype genome-wide association study supports shared genetic etiology between skin and gastrointestinal tract diseases

28 May 2025

Abstract excerpt

The comorbidity of skin and gastrointestinal tract (GIT) diseases, primarily driven by the gut-skin axis (GSA), is well-known. However, the genetic contribution to the GSA remains unclear. Here, using genome-wide association study (GWAS) summary statistics from European populations, we performed genome-wide pleiotropic analysis to investigate the shared genetic basis and causal associations between skin and GIT...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Eosinophilic Esophagitis
Share to Helicobacter pylori-related gastroenterology studies
Share to IL-33, ST2, and ILC Pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40441863
DOI: 10.7555/jbr.39.20250166

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cross-phenotype genome-wide association study supports shared genetic etiology between skin and gastrointestinal tract diseasesPMID 40441863Read ↗

An atlas of the shared genetic architecture between atopic and gastrointestinal diseases.Semantic proximity Read ↗

Cross-disorder genetic analysis of immune diseases reveals distinct disease groups and associated genes that converge on common pathogenic pathwaysSemantic proximity Read ↗

Multi-trait and cross-population genome-wide association studies across autoimmune and allergic diseases identify shared and distinct genetic componentSemantic proximity Read ↗

Evidence for the gut‐skin axis: Common genetic structures in inflammatory bowel disease and psoriasisSemantic proximity Read ↗

Cross-trait mapping of shared susceptibility across inflammatory bowel disease and spondyloarthropathies.Semantic proximity Read ↗

Integrative systems biology framework discovers common gene regulatory signatures in multiple mechanistically distinct inflammatory skin diseasesSemantic proximity Read ↗

Genome-Wide Pleiotropic Analyses Characterize the Genetic Etiology Shared between Cardiovascular and Gastrointestinal Tract DiseasesSemantic proximity Read ↗

Genetic and observational associations of lung function with gastrointestinal tract diseases: pleiotropic and mendelian randomization analysis.Semantic proximity Read ↗

Shared Genetics Implicate Gut Microbiota and Immunity in Anterior Uveitis and Inflammatory Bowel Disease.Semantic proximity Read ↗

Clinical, serologic, and genetic factors associated with pyoderma gangrenosum and erythema nodosum in inflammatory bowel disease patients.Semantic proximity Read ↗

Hidradenitis Suppurativa: A Perspective on Genetic Factors Involved in the DiseaseSemantic proximity Read ↗

Genetic associations between asthma and type 2 inflammatory diseases: Insights from pleiotropic loci and genes: shared genetics of Type 2 Iinflammatory diseases: Shared Genetics of Type 2 Inflammatory Diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.