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Article

Cell-type-resolved genetic variation shapes inflammatory bowel disease risk.

Nature - 1 Aug 2026

Alegbe Tobi, Harris Bradley T, Fachal Laura, Ramirez-Navarro Lucia, Tutert Marcus, Krzak Monika, Ghouraba Mennatallah, Strickland Michelle, Ozols Matiss, Cohen Celeste E, Khullar Saniya, Khabirova Eleonora, Panousis Nikolaos I, Ochoa David, Wana Noor, Hu May Xueqi, Skelton Jason, Ostermayer Jasmin, Cheam Kimberly Ai Xian, Leland Taylor D, Gu Yong, Dawson Claire, Thompson Tina, Arestang Kenneth, Nishad Nilanga, Brezina Biljana, Caballes Charry Queen, Garri Wendy, Leonard Steven, Iyer Vivek, Parkes Miles, Wallace Chris, McIntyre Rebecca E, Martin Cristina Cotobal, Jones Gareth-Rhys, Raine Tim, Anderson Carl A

Abstract excerpt

Most genetic variants associated with complex diseases lie in non-coding regions1, complicating efforts to identify effector genes and relevant cell types. Here we map cis-expression quantitative trait loci (eQTLs) across 2.2 million single cells using intestinal biopsies and blood from 421 individuals, including 125 with inflammatory bowel disease (IBD). Cell-type-level eQTLs were more distal to transcription...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42236949
DOI: 10.1038/s41586-026-10627-z
PMCID: PMC13441992

Genes

MAML2
MYC
PSEN2
ZMIZ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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