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Article

An atlas of the shared genetic architecture between atopic and gastrointestinal diseases.

Communications biology - 24 Dec 2024

Qi Cancan, Li An, Su Fengyuan, Wang Yu, Zhou Longyuan, Tang Ce, Feng Rui, Mao Ren, Chen Minhu, Chen Lianmin, Koppelman Gerard H, Bourgonje Arno R, Zhou Hongwei, Hu Shixian

Abstract excerpt

Comorbidity among atopic diseases (ADs) and gastrointestinal diseases (GIDs) has been repeatedly demonstrated by epidemiological studies, whereas the shared genetic liability remains largely unknown. Here we establish an atlas of the shared genetic architecture between 10 ADs or related traits and 11 GIDs, comprehensively investigating the comorbidity-associated genomic regions, cell types, genes and genetically...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39719505
DOI: 10.1038/s42003-024-07416-7
PMCID: PMC11668890

Genes

CD4
GPX4

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