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Article

Spatial genetic mapping links shared inflammatory bowel disease liability to adult immune-epithelial lesion contexts.

Frontiers in immunology - 1 Jan 2026

Tao Guangyi, Du Hanzhe, Zhao Jun, Zeng Zhonghe, Cui Junwu, Lei Longming

Abstract excerpt

Background: Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), shows marked clinical heterogeneity despite a shared immune-genetic background. The adult spatial contexts through which inherited IBD susceptibility is expressed remain unclear. Methods: We integrated GWAS summary statistics for overall IBD, CD, and UC with LDSC, stratified LDSC, LDSC-SEG, MAGMA, PoPS, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42488658
DOI: 10.3389/fimmu.2026.1853177
PMCID: PMC13388401

Genes

CCL2
JAK2
CXCL8
IL1B
IL23R
NOD2
OCLN
PYCARD
STAT3
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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