Article
Lower Dose-Normalized Tacrolimus Exposure in CYP3A5*6 vs. *3 Loss-of-Function Allele Carriers: A Longitudinal Retrospective Real-World Study in Kidney Transplant Recipients.
Clinical pharmacology and therapeutics - 1 Apr 2026
Levens Amar D, Moes Dirk Jan A R, Boer Yanick, de Vries Aiko P J, de Vries Dorottya K, van der Helm Danny, Meziyerh Soufian, Roelen Dave L, Böhringer Stefan, Van Gelder Teun, Swen Jesse J
Abstract excerpt
Pharmacogenomic research has historically focused on individuals of European ancestry, leading to the underrepresentation of genetic variants common in non-European populations. This bias is exemplified by CYP3A5*6, a functionally consequential variant common in individuals of African ancestry (MAF: 11-19%) but virtually absent in Europeans (MAF: 0.15%). We conducted a retrospective, longitudinal cohort study...
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