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Article

Assessing the Utility of a Genotype-Guided Tacrolimus Equation in African American Kidney Transplant Recipients: A Single Institution Retrospective Study.

Journal of clinical pharmacology - 1 Aug 2024

Obayemi Joy E, Callans Lauren, Nair Nikhil, Gao Hui, Gandla Divya, Loza Bao-Li, Gao Sarah, Mohebnasab Maedeh, Trofe-Clark Jennifer, Jacobson Pamala, Keating Brendan

Abstract excerpt

Tacrolimus metabolism is heavily influenced by the CYP3A5 genotype, which varies widely among African Americans (AA). We aimed to assess the performance of a published genotype-informed tacrolimus dosing model in an independent set of adult AA kidney transplant (KTx) recipients. CYP3A5 genotypes were obtained for all AA KTx recipients (n = 232) from 2010 to 2019 who met inclusion criteria at a single transplant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38766706
DOI: 10.1002/jcph.2461

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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