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Article

Precision Dosing for Tacrolimus Using Genotypes and Clinical Factors in Kidney Transplant Recipients of European Ancestry.

Journal of clinical pharmacology - 1 Aug 2021

Al-Kofahi Mahmoud, Oetting William S, Schladt David P, Remmel Rory P, Guan Weihua, Wu Baolin, Dorr Casey R, Mannon Roslyn B, Matas Arthur J, Israni Ajay K, Jacobson Pamala A

Abstract excerpt

Genetic variation in the CYP3A4 and CYP3A5 (CYP3A4/5) genes, which encode the key enzymes in tacrolimus metabolism, is associated with tacrolimus clearance and dose requirements. Tacrolimus has a narrow therapeutic index with high intra- and intersubject variability, in part because of genetic variation. High tacrolimus clearance and low trough concentration are associated with a greater risk for rejection,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33512723
DOI: 10.1002/jcph.1823
PMCID: PMC11240873

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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