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Impact of CYP3A5 Gene Polymorphisms on Tacrolimus Pharmacokinetics and Renal Allograft Rejection in Kidney Transplant Recipients: A Meta-Analysis Across Ethnic Populations

2025-09-15

Abstract excerpt

<title>Abstract</title> <p>Tacrolimus is a cornerstone immunosuppressant in kidney transplantation, but its pharmacokinetics show significant interindividual variability, primarily due to CYP3A5 polymorphisms. This meta-analysis evaluated the impact of CYP3A5 expresser (*1/*1, *1/*3) versus non-expresser (*3/*3) genotypes on tacrolimus concentration-to-dose (Co/D) ratios and renal allograft rejection. Fifty-one s...

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Literature Corpus work
f7bc344c-c88e-55d8-b5b0-47e9476277d6
DOI
10.21203/rs.3.rs-7490941/v1
Open publication

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Impact of CYP3A5 Gene Polymorphisms on Tacrolimus Pharmacokinetics and Renal Allograft Rejection in Kidney Transplant Recipients: A Meta-Analysis Across Ethnic PopulationsDOI 10.21203/rs.3.rs-7490941/v1
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