Article
Genomewide Association Study of Tacrolimus Concentrations in African American Kidney Transplant Recipients Identifies Multiple CYP3A5 Alleles.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Feb 2016
Oetting W S, Schladt D P, Guan W, Miller M B, Remmel R P, Dorr C, Sanghavi K, Mannon R B, Herrera B, Matas A J, Salomon D R, Kwok P-Y, Keating B J, Israni A K, Jacobson P A
Abstract excerpt
We previously reported that tacrolimus (TAC) trough blood concentrations for African American (AA) kidney allograft recipients were lower than those observed in white patients. Subtherapeutic TAC troughs may be associated with acute rejection (AR) and AR-associated allograft failure. This variation in TAC troughs is due, in part, to differences in the frequency of the cytochrome P450 CYP3A5*3 allele (rs776746,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.