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Article

Combined Role of CYP3A4 and CYP3A5 genetic variants in tacrolimus dose-adjusted trough levels: a clinical retrospective study in kidney transplant patients.

The pharmacogenomics journal - 6 Jan 2026

Tsironi Anna, Mendrinou Effrosyni, Siamoglou Stavroula, Kydonopoulou Kyriaki, John Anne, Gerou Alexandra, Gerou Spyridon, Ali Bassam R, Papasotiriou Marios, Patrinos George P

Abstract excerpt

Tacrolimus, a calcineurin inhibitor with a narrow therapeutic index, requires precise dosing to optimize efficacy and minimize adverse effects in kidney transplant recipients. Although CYP3A5 genetic variants influence tacrolimus pharmacokinetics, they do not fully explain inter-individual differences. This retrospective study evaluated the combined impact of CYP3A4 [*1B (rs2740574), *1 G (rs2242480), *22...

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Source

Identifiers

PMID: 41491289
DOI: 10.1038/s41397-025-00395-w

Genes

CYP3A4
CYP3A5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Combined Role of CYP3A4 and CYP3A5 genetic variants in tacrolimus dose-adjusted trough levels: a clinical retrospective study in kidney transplant patients.PMID 41491289Read ↗

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