Article
Novel polymorphisms associated with tacrolimus trough concentrations: results from a multicenter kidney transplant consortium.
Transplantation - 15 Feb 2011
Jacobson Pamala A, Oetting William S, Brearley Ann M, Leduc Robert, Guan Weihau, Schladt David, Matas Arthur J, Lamba Vishal, Julian Bruce A, Mannon Rosalyn B, Israni Ajay
Abstract excerpt
BACKGROUND: The CYP4503A5*1 genotype is associated with lower tacrolimus concentrations. Although its effect is important, it incompletely explains the variability in tacrolimus concentrations and has a relatively low minor allele frequency in whites relative to African Americans (AA). METHODS: We studied clinical and recipient genetic correlates of dose-normalized tacrolimus troughs (n=12,277) in the first 6...
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