Article
A Review of Population Pharmacokinetic Models and Dosing Algorithms Assessing the Influence of CYP3A5 Genotype and Other Clinical Covariates on Tacrolimus Pharmacokinetics.
Clinical pharmacokinetics - 1 Sept 2026
Randolph Riley M, Jubas Sara, Gong Li, Venkataramanan Raman, Khatri Dhrita, Jacobson Pamala A, Metz David, Crona Daniel J
Abstract excerpt
Tacrolimus is a narrow therapeutic index drug with wide intrapatient and interpatient pharmacokinetic variability and cytochrome P450 3A5 (CYP3A5) genotype-guided dosing recommendations. This review aimed to evaluate population pharmacokinetic models and dosing algorithms across all treatment settings that analyzed the influence of CYP3A5 genotypic variation plus additional clinical covariates on tacrolimus...
Read the complete abstract on PubMedTopics
- Humans
- Tacrolimus
- Cytochrome P-450 CYP3A
- Immunosuppressive Agents
- Genotype
- Models, Biological