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Article

Steroid-tacrolimus drug-drug interaction and the effect of CYP3A genotypes.

British journal of clinical pharmacology - 1 Nov 2024

Saqr Abdelrahman, Al-Kofahi Mahmoud, Mohamed Moataz, Dorr Casey, Remmel Rory P, Onyeaghala Guillaume, Oetting William S, Guan Weihua, Mannon Roslyn B, Matas Arthur J, Israni Ajay, Jacobson Pamala A

Abstract excerpt

AIMS: Tacrolimus, metabolized by CYP3A4 and CYP3A5 enzymes, is susceptible to drug-drug interactions (DDI). Steroids induce CYP3A genes to increase tacrolimus clearance, but the effect is variable. We hypothesized that the extent of the steroid-tacrolimus DDI differs by CYP3A4/5 genotypes. METHODS: Kidney transplant recipients (n = 2462) were classified by the number of loss of function alleles (LOF) (CYP3A5*3,...

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Identifiers

PMID: 38994750
DOI: 10.1111/bcp.16172
PMCID: PMC12872032

Genes

CYP3A4
CYP3A5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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