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Article

Composite CYP3A (CYP3A4 and CYP3A5) phenotypes and influence on tacrolimus dose adjusted concentrations in adult heart transplant recipients.

The pharmacogenomics journal - 15 Feb 2024

Liu Michelle, Hernandez Savine, Aquilante Christina L, Deininger Kimberly M, Lindenfeld Joann, Schlendorf Kelly H, Van Driest Sara L

Abstract excerpt

CYP3A5 genetic variants are associated with tacrolimus metabolism. Controversy remains on whether CYP3A4 increased [*1B (rs2740574), *1 G (rs2242480)] and decreased function [*22 (rs35599367)] genetic variants provide additional information. This retrospective cohort study aims to address whether tacrolimus dose-adjusted trough concentrations differ between combined CYP3A (CYP3A5 and CYP3A4) phenotype groups....

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Topics

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Share to Cytochrome P-450 CYP3A
Share to Genotype
Share to Heart Transplantation
Share to Immunosuppressive Agents
Share to Phenotype
Share to Polymorphism, Single Nucleotide
Share to Tacrolimus
Share to Transplant Recipients

Source

Open in PubMed Open full text

Identifiers

PMID: 38360955
DOI: 10.1038/s41397-024-00325-2
PMCID: PMC13261553

Genes

CYP3A4
CYP3A5

Provenance

PubMed metadata and Literature Corpus relationships.

Related research

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Composite CYP3A (CYP3A4 and CYP3A5) phenotypes and influence on tacrolimus dose adjusted concentrations in adult heart transplant recipients.PMID 38360955Read ↗

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