Article
Hereditary diffuse gastric cancer in progress: Comparative lessons from Lynch syndrome.
European journal of human genetics : EJHG - 1 Sept 2026
Pereira Joana, Carvalho Luísa, Melo Soraia, Carneiro Patrícia, Fernandes Maria Sofia, Seruca Raquel, Figueiredo Joana
Abstract excerpt
Hereditary diffuse gastric cancer (HDGC) and Lynch syndromes are dominant hereditary diseases caused by pathogenic germline variants in specified genes, and characterised by a broad spectrum of malignancies. Whereas HDGC is associated with CDH1 and CTNNA1 variants and defined by an increased risk of diffuse gastric cancer and lobular breast cancer, Lynch syndrome results from alterations in mismatch repair genes,...
Read the complete abstract on PubMedTopics
- Humans
- Colorectal Neoplasms, Hereditary Nonpolyposis
- Stomach Neoplasms
- Cadherins
- Genetic Predisposition to Disease