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Article

Hereditary Diffuse Gastric Cancer: Molecular Genetics, Biological Mechanisms and Current Therapeutic Approaches.

International journal of molecular sciences - 15 Jul 2022

Cosma Lidia-Sabina, Schlosser Sophie, Tews Hauke C, Müller Martina, Kandulski Arne

Abstract excerpt

Hereditary diffuse gastric cancer is an autosomal dominant syndrome characterized by a high prevalence of diffuse gastric cancer and lobular breast cancer. It is caused by inactivating mutations in the tumor suppressor gene CDH1. Genetic testing technologies have become more efficient over the years, also enabling the discovery of other susceptibility genes for gastric cancer, such as CTNNA1 among the most...

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Identifiers

PMID: 35887173
DOI: 10.3390/ijms23147821
PMCID: PMC9319245

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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