Article
Overview on new progress of hereditary diffuse gastric cancer with CDH1 variants.
Tumori - 1 Oct 2020
Hu Mu-Ni, Hu Shu-Hui, Zhang Xing-Wei, Xiong Shu-Min, Deng Huan
Abstract excerpt
Hereditary diffuse gastric cancer (HDGC), comprising 1%-3% of gastric malignances, has been associated with CDH1 variants. Accumulating evidence has demonstrated more than 100 germline CDH1 variant types. E-cadherin encoded by the CDH1 gene serves as a tumor suppressor protein. CDH1 promoter hypermethylation and other molecular mechanisms resulting in E-cadherin dysfunction are involved in the tumorigenesis of...
Topics
- Antigens, CD
- Cadherins
- Carcinogenesis
- Gastrectomy
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Humans
- Stomach Neoplasms