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Article

Hereditary Diffuse Gastric Cancer.

Gastroenterology - 1 Apr 2023

Decourtye-Espiard Lyvianne, Guilford Parry

Abstract excerpt

Hereditary diffuse gastric cancer (HDGC) is a dominantly inherited cancer syndrome characterized by a high incidence of diffuse gastric cancer (DGC) and lobular breast cancer (LBC). HDGC is caused by germline mutations in 2 genes involved in the epithelial adherens junction complex, CDH1 and CTNNA1. We discuss the genetics of HDGC and the variability of its clinical phenotype, in particular the variable...

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Identifiers

PMID: 36740198
DOI: 10.1053/j.gastro.2023.01.038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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