Article
Hereditary diffuse gastric cancer (HDGC). An overview.
Clinics and research in hepatology and gastroenterology - 1 Apr 2022
Taja-Chayeb L, Vidal-Millán S, Trejo-Becerril C, Pérez-Cárdenas E, Chávez-Blanco A, Domínguez-Gómez G, González-Fierro A, Romo-Pérez A, Dueñas-González A
Abstract excerpt
It is estimated that up to 10% of gastric carcinomas show familial aggregation. In contrast, around 1-3 % (approximately 33,000 yearly) are genuinely hereditary. Hereditary diffuse gastric cancer (HDGC) is a rare malignancy characterized by autosomal dominant inheritance of pathological variants of the CDH1 and CTNNA1 genes encoding the adhesion molecules E-cadherin and α-catenin, respectively. The multifocal...
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