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Diffuse gastric cancer: histologic, molecular, and genetic basis of disease

10 Mar 2020

Abstract excerpt

Diffuse gastric cancer (DGC) is a distinct histopathologic and molecular disease, characterized by mutations in CDH1, RHOA, and others. In addition, DGC is associated with familial syndromes, including hereditary DGC and germline mutation in CDH1. Clinically, this subtype of gastric adenocarcinoma is associated with a poor prognosis and possible resistance to available systemic therapies. An understanding of the...

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PMID: 33073047
DOI: 10.21037/tgh.2020.01.02

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