Current advances in understanding the molecular profile of hereditary diffuse gastric cancer and its clinical implications.

doi:10.1186/s13046-023-02622-3

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Article

Current advances in understanding the molecular profile of hereditary diffuse gastric cancer and its clinical implications.

Journal of experimental & clinical cancer research : CR - 4 Mar 2023

Lim Hui Jun, Zhuang Lizhe, Fitzgerald Rebecca C

Abstract excerpt

Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome attributed to germline CDH1 mutations that carries a high risk for early onset DGC. HDGC raises a significant health issue due to its high penetrance and mortality unless diagnosed early. The definitive treatment is...

Topics

Humans
Stomach Neoplasms
Adenocarcinoma
Cadherins
Cytoplasm
Mutation

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