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Article

Undetected rifampicin-resistant tuberculosis associated with rpoB I491F and V170F mutations in Botswana: Diagnostic implications.

Journal of global antimicrobial resistance - 1 Jan 2026

Mogashoa Tuelo, Ngom Justice T, Loubser Johannes, Seru Kedumetse, Molefi Tuduetso, Stephen One, Musonda Rosemary M, Gaseitsiwe Simani, Warren Robin M, Dippenaar Anzaan, Streicher Elizabeth M, Moyo Sikhulile

Abstract excerpt

BACKGROUND: Undetected rifampicin resistance is a threat to global tuberculosis (TB) control efforts by delaying effective treatment. In different studies, non-canonical rpoB mutations outside the rifampicin resistance-determining region have been reported at varying prevalences by country. Here, we report cases of rifampicin resistance in Botswana that were missed by the routine molecular diagnostic assays....

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Identifiers

PMID: 41391587
DOI: 10.1016/j.jgar.2025.12.005
PMCID: PMC13329411

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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