Detection of I491F and V170F rpoB mutations associated with misdiagnosis of rifampicin resistance among patients with drug-susceptible tuberculosis treatment failure, Myanmar, 2022.

Abstract excerpt

OBJECTIVE: Detecting rifampicin (RIF) resistance is crucial in selecting tuberculosis (TB) treatment. Recently, several studies reported that I491F and V170F rpoB mutations were found with a varying prevalence. This study aimed to find out RIF resistance missed by routine diagnostic assays using next generation genome sequencing tool. METHODS: Sputum specimens from first-line TB treatment failed patients...

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• Antibiotics, Antitubercular
• Diagnostic Errors
• DNA-Directed RNA Polymerases
• Myanmar
• Rifampin