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Article

Dissecting rifampicin heteroresistance in Mycobacterium tuberculosis: integrating whole-genome sequencing with phenotypic and clonal validation.

Journal of medical microbiology - 1 Jul 2025

Vallejos-Sanchez Katherine, Taquiri-Díaz Diego A, Romero-Rodriguez Omar A, Vargas-Ruiz A Paula, Coronel Jorge, Torres Arturo, Perez-Martinez Jose L, Ochoa-Ortiz Adiana, Gilman Robert H, Grandjean Louis, Cohen-Gonsaud Martin, Zimic Mirko, Sheen Patricia

Abstract excerpt

Introduction. This study underscores the critical role of identifying heteroresistant infections of Mycobacterium tuberculosis (Mtb) in enhancing the diagnostics of tuberculosis (TB). These conditions complicate diagnostics and treatment, underlining the need for advanced techniques to detect and characterize resistant populations effectively.Hypothesis/Gap statement. Current diagnostics may fail to identify...

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Identifiers

PMID: 40737173
DOI: 10.1099/jmm.0.002048
PMCID: PMC12310241

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