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Emerging Rifampicin Resistance in M. tuberculosis: First Report on Characterization of a Novel rpoB(Ser431Phe) Mutation and Phylogenetic Lineages in Khyber Pakhtunkhwa, Pakistan

2025-09-04

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<title>Abstract</title> Background First-line drug resistance in <italic>Mycobacterium tuberculosis</italic> (MTB) is a major challenge in high-burden settings like Pakistan, primarily linked to mutations in <italic>rpoB, inhA, katG, embA, embB, embC</italic>, and <italic>pncA</italic>. The emergence of novel, region-specific variants underscores the need for comprehensive genomic profiling to enhance diagnost...

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Literature Corpus work: ca6162f0-c92b-533e-9cef-69252bc0053f
DOI: 10.21203/rs.3.rs-7142035/v1

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