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Article

Decoding antibiotic resistance in tuberculosis: Role of RRDR and non-RRDR mutations in diagnostic perspectives.

Biochemical and biophysical research communications - 7 May 2026

Hazarika Risha, Patra Sanjukta

Abstract excerpt

Rifampicin resistance continues to pose a challenge to successful tuberculosis (TB) control, mainly driven by mutations in the rpoB gene of Mycobacterium tuberculosis. Although most diagnostic tools, such as Xpert MTB/RIF, Xpert Ultra, and line probe assays, focus on the standard 81-bp rifampicin resistance-determining region (RRDR), recent findings emphasize the critical role of non-RRDR mutations in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41833077
DOI: 10.1016/j.bbrc.2026.153563

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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