Article
Rifampicin resistance conferring mutations among Mycobacterium tuberculosis strains in Rwanda.
International journal of mycobacteriology - 1 Jan 2000
Cuella-Martin Isabel, Semuto Ngabonziza Jean Claude, Torrea Gabriela, Meehan Conor Joseph, Mulders Wim, Ushizimpumu Bertin, De Weerdt Louise, Keysers Jelle, De Rijk Willem Bram, Decroo Tom, De Jong Bouke C, Rigouts Leen
Abstract excerpt
Background: The World Health Organization-endorsed phenotypic and genotypic drug-susceptibility testing (gDST/pDST) assays for the detection of rifampicin-resistant (RR) tuberculosis (TB), may miss some clinically relevant rpoB mutants, including borderline mutations and mutations outside the gDST-targeted hotspot region. Sequencing of the full rpoB gene is considered the reference standard for rifampicin DST but...
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