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First detection of a Mycobacterium tuberculosis XDR clinical isolate harbouring an RpoB I491F mutation in a Ukrainian patient treated in Germany, October 2023.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin - 1 Jul 2024

Friesen Inna, Dreyer Viola, Klingmüller Angela, Zuber Sylvia, Hoffmann Ada M, Suárez Isabelle, Schütz Beatrice, Preßel Tim, Andres Sönke, Niemann Stefan, Rybniker Jan

Abstract excerpt

This report documents the case of a Ukrainian patient infected with an extensively drug-resistant (XDR) lineage 2 Mycobacterium tuberculosis strain harbouring the rifampicin resistance mutation RpoB I491F. This mutation is not detected by routine molecular WHO-recommended rapid diagnostics, complicating the detection and treatment of these strains. The occurrence of such mutations underscores the need for...

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Identifiers

PMID: 38994601
DOI: 10.2807/1560-7917.ES.2024.29.28.2400420
PMCID: PMC11241856

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