Article

Identification of endothelial-to-mesenchymal transition gene signatures in single-cell transcriptomics of human atherosclerotic tissue

2023-07-18

Abstract excerpt

<h4>Rationale</h4> Endothelial cells can differentiate into mesenchymal-like cells via endothelial to mesenchymal transition (EndoMT). In murine models, cell transitions of EndoMT have been assessed with lineage tracing techniques. Knowledge on molecular mechanisms of EndoMT in human vascular lesions is scarce as studies in human atherosclerosis are limited by observational study designs such as histo-pathologica...

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Literature Corpus work: 2519cc72-7190-5588-b507-09f5f6bcebab
DOI: 10.1101/2023.07.18.549599

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