Article

Atlas of the Human Brain Imaging-derived Phenotypes and Disease Risk

2025-12-04

Abstract excerpt

<title>Abstract</title> <p>Leveraging multimodal magnetic resonance imaging (MRI) and linked health records from 64,785 participants, we assessed associations between 505 brain imaging-derived phenotypes (IDPs)—including T1-weighted, diffusion, and resting-state functional MRI measures—and 738 incident diseases, establishing the largest atlas of brain–disease risk to date. Across 370,000 tests, 1,491 significant...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0d80f006-2fea-5cb4-9653-4ef7ac1d139f
DOI: 10.21203/rs.3.rs-8140747/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Atlas of the Human Brain Imaging-derived Phenotypes and Disease RiskDOI 10.21203/rs.3.rs-8140747/v1Read

Atlas of the Human Brain Imaging-derived Phenotypes and Disease RiskSemantic proximity Read

Atlas of human brain imaging-derived phenotypes and disease risk.Semantic proximity Read

Multi-organ imaging-derived polygenic indexes for brain and body healthSemantic proximity Read

Neuropredictome: a data-driven predictome for cognitive, psychiatric, medical, and lifestyle factors on the brainSemantic proximity Read

Genetic Interplay Between White Matter Hyperintensities and Alzheimer’s Disease: A Brain-Body PerspectiveSemantic proximity Read

Prediction of future brain disorder risk using imaging data in 46,090 adultsSemantic proximity Read

Multi-organ network of cardiometabolic disease-depression multimorbidity revealed by phenotypic and genetic analyses of MR images.Semantic proximity Read

Mega-analysis of brain structural covariance, genetics, and clinical phenotypesSemantic proximity Read

Joint multi-omics profiling of brain and body health in agingSemantic proximity Read

A spatially resolved genomic–molecular atlas of human white‑matter microstructureSemantic proximity Read

Cross-tissue omics-guided drug repurposing triangulates novel targetable mechanisms for Alzheimer’s disease and candidate genetic biomarkers for treatment stratificationSemantic proximity Read

Shared Molecular Landscape of Human Brain Structure and Systemic MetabolismSemantic proximity Read