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Investigating multidimensional associations between obesity-related traits and brain health, and identifying potential mechanisms.

Medicine - 9 Jan 2026

Chen Shuyuan, Wen Jie, Tan Zeming, Chen Yuyao, Xia Zhiwei, Liu Hongwei

Abstract excerpt

The impact of obesity on brain health, spanning cerebrovascular disease, cognition, and neuroanatomy, remains incompletely understood. We conducted 2-sample Mendelian randomization to assess the causal effects of obesity traits on brain health outcomes. Potential biological pathways were explored using transcriptome-wide association study analyses. We further examined associations in the National Health and...

Topics

Humans
Obesity
Body Mass Index
Brain
Stroke
Nutrition Surveys
Waist-Hip Ratio
Waist Circumference
Mendelian Randomization Analysis
Female
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Cognition

Phenotype

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Identifiers

PMID: 41517787
DOI: 10.1097/MD.0000000000046831
PMCID: PMC12795085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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