Article

Unique genetic architecture of CSF and brain metabolites pinpoints the novel targets for the traits of human wellness

2023-06-09

Abstract excerpt

<title>Abstract</title> <p>Brain metabolism perturbation can contribute to traits and diseases. We conducted the first large-scale CSF and brain genome-wide association studies, which identified 219 independent associations (59.8% novel) for 144 CSF metabolites and 36 independent associations (55.6% novel) for 34 brain metabolites. Most of the novel signals (97.7% and 70.0% in CSF and brain) were tissue specific....

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Literature Corpus work: 9ec54886-4c30-59f0-97fb-c90dc9ebb2ee
DOI: 10.21203/rs.3.rs-2923409/v1

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