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Article

Adipose tissue coregulates cognitive function

11 Aug 2023

Abstract excerpt

Obesity is associated with cognitive decline. Recent observations in mice propose an adipose tissue (AT)–brain axis. We identified 188 genes from RNA sequencing of AT in three cohorts that were associated with performance in different cognitive domains. These genes were mostly involved in synaptic function, phosphatidylinositol metabolism, the complement cascade, anti-inflammatory signaling, and vitamin...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 37566655
DOI: 10.1126/sciadv.adg4017

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