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Article

The impact of collider bias on genetic prediction in psychotic disorders.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2026

Asim Amna, Yang Yuan, Heilbronner Urs, Schulze Thomas, Lencz Todd, Vassos Evangelos, Clouston Sean A P, Kotov Roman, Jonas Katherine

Abstract excerpt

Polygenic risk scores (PRS) have potential utility as biomarkers of psychiatric disorders. However, the potential utility of some PRS has been much clearer than others. The schizophrenia PRS has been consistently associated with diagnosis, symptom severity, and other correlates of schizophrenia. Yet despite the close genetic correlation (rg = 0.69) between bipolar disorder and schizophrenia, the bipolar (BP) PRS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41266786
DOI: 10.1038/s41386-025-02285-y
PMCID: PMC12708778

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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