Article

Impact of Selection Bias on Polygenic Risk Score Estimates in Healthcare Settings

2022-07-22

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Hospital-based biobanks have become an increasingly prominent resource for evaluating the clinical impact of disease-related polygenic risk scores (PRS). However, biobank cohorts typically rely on selection of volunteers who may differ systematically from non-participants. <h4>Methods</h4> PRS weights for schizophrenia, bipolar disorder, and depression were derived using summa...

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Literature Corpus work: c4a13a3d-f0b4-5667-870a-8c2e7a26317e
DOI: 10.1101/2022.07.20.22277710

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