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Article

Reactive astrocyte-related pathogenic genes in Parkinson's disease: A multi-omics Mendelian randomization study.

Journal of Parkinson's disease - 1 Feb 2026

Wang Huixi, Hu Jiahao, Mo Bin, Li Junju, Cai Haixin, Li Qingzhi

Abstract excerpt

BackgroundReactive astrocytes are one of the pathological features of Parkinson's disease (PD) and are associated with neuroinflammation and neuronal damage.ObjectiveTo explore the causal relationship between reactive astrocyte-related genes and PD through the summary data-based Mendelian randomization (SMR).MethodsWe combined these reactive astrocyte-related Quantitative Trait Loci (QTLs) data with PD...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41252303
DOI: 10.1177/1877718X251395514
PMCID: PMC13347559

Genes

MAPK1
CLEC3B
CTSB
PLAU

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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