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Article

Integrative Multi-Omics Mendelian Randomization Highlights Causal Autophagy-Related Genes for Amyotrophic Lateral Sclerosis.

Brain and behavior - 1 Apr 2026

Jiang Zheng, Ren Yan-Lin, Gu Xiao-Jing, Su Wei-Ming, Duan Qing-Qing, Yin Kang-Fu, Cao Bei, Li Jing-Yu, Yan Bo, Chen Yong-Ping

Abstract excerpt

BACKGROUND: Autophagy dysregulation has been implicated in the toxic protein aggregates of amyotrophic lateral sclerosis (ALS). However, the causal relationship between impaired autophagy and ALS remains ambiguous, necessitating further elucidation. METHODS: This Mendelian randomization (MR) study employs a two-sample design, utilizing genetic instruments to proxy autophagy dysregulation as the exposure and ALS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41917768
DOI: 10.1002/brb3.71366
PMCID: PMC13112017

Genes

FNBP1
IDUA
USP35
PFN1
SQSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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