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The causal relationship between Parkinson’s disease and inflammatory cytokines: a bidirectional two-sample Mendelian randomization study

2024-11-04

Abstract excerpt

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the substantia nigra and striatum, leading to debilitating motor symptoms. Emerging evidence suggests a significant role of neuroinflammation in PD pathogenesis, particularly through the upregulation of inflammatory cytokines. However, the causal relationship between inflammatory mediat...

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Literature Corpus work
86d6f22b-f3d6-571f-bf7a-2aad134b577e
DOI
10.22541/au.173074533.38192598/v1
Open publication

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