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Integrating Mendelian Randomization With Single-Cell Sequencing Data Reveals the Causal Effect and Related Mechanisms of Smoking on Parkinson’s Disease

20 Jul 2024

Abstract excerpt

INTRODUCTION: Smoking (nicotine) has been reported to possibly be neuroprotective and conducive to patients with early Parkinson's disease (PD). However, the causal effect of smoking on PD and the molecular mechanisms of smoking-related genes (SRGs) are vague. AIMS AND METHODS: First, genome-wide association study summary data on smoking (ukb-b-6244) and PD (ieu-b-7) were retrieved from the Integrative...

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PMID: 39030896
DOI: 10.1093/ntr/ntae180

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