Article
Astrocytic HMGCR-Mediated Cholesterol Alleviated Parkinson's Disease Phenotypes by Inhibiting NF-κB Neuroinflammation.
Molecular neurobiology - 16 Jul 2026
Tian Xiaofeng, Liu Qing, Zhang Jiacheng, Du Huijiao, Wei Zhaoran, Sun Linjie, Gao Jiamin, Zhao Ruiting, Wang Lei, Zhang Yizhou
Abstract excerpt
In recent years, the association between abnormal cholesterol metabolism and Parkinson's disease (PD) has attracted considerable attention, but the specific mechanism remains controversial. First, we used Mendelian Randomization (MR) analysis to clarify the relationship between cholesterol and PD. Subsequently, scRNA-seq and RNA-seq were used to identify the crucial role of astrocyte...
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