Article

Standardized Measurement of Type 1 Diabetes Polygenic Risk Across Multi-Ancestry Population Cohorts

2025-01-17

Abstract excerpt

Type 1 diabetes (T1D) polygenic risk scores (PRS) are effective tools for discriminating T1D from other diabetes types and predicting T1D risk, with applications in screening and intervention trials. A previously published T1D Genetic Risk Score 2 (GRS2) is widely adopted, but challenges in standardization and accessibility have hindered broader clinical and research utility. To address this, we introduce GRS2x, a...

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Literature Corpus work: 7a209d0b-6521-5139-85c4-6cf7adf00d30
DOI: 10.1101/2025.01.16.25320691

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