Article
Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations.
Genome medicine - 29 Jun 2022
Ge Tian, Irvin Marguerite R, Patki Amit, Srinivasasainagendra Vinodh, Lin Yen-Feng, Tiwari Hemant K, Armstrong Nicole D, Benoit Barbara, Chen Chia-Yen, Choi Karmel W, Cimino James J, Davis Brittney H, Dikilitas Ozan, Etheridge Bethany, Feng Yen-Chen Anne, Gainer Vivian, Huang Hailiang, Jarvik Gail P, Kachulis Christopher, Kenny Eimear E, Khan Atlas, Kiryluk Krzysztof, Kottyan Leah, Kullo Iftikhar J, Lange Christoph, Lennon Niall, Leong Aaron, Malolepsza Edyta, Miles Ayme D, Murphy Shawn, Namjou Bahram, Narayan Renuka, O'Connor Mark J, Pacheco Jennifer A, Perez Emma, Rasmussen-Torvik Laura J, Rosenthal Elisabeth A, Schaid Daniel, Stamou Maria, Udler Miriam S, Wei Wei-Qi, Weiss Scott T, Ng Maggie C Y, Smoller Jordan W, Lebo Matthew S, Meigs James B, Limdi Nita A, Karlson Elizabeth W
Abstract excerpt
BACKGROUND: Type 2 diabetes (T2D) is a worldwide scourge caused by both genetic and environmental risk factors that disproportionately afflicts communities of color. Leveraging existing large-scale genome-wide association studies (GWAS), polygenic risk scores (PRS) have shown promise to complement established clinical risk factors and intervention paradigms, and improve early diagnosis and prevention of T2D....
Topics
- Bayes Theorem
- Diabetes Mellitus, Type 2
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans