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Article

Long-read sequencing reveals genomic and epigenomic variation in the dark genome of human Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Nov 2025

Ramirez Paulino, Sun Wenyan, Dehkordi Shiva Kazempour, Zare Habil, Pascarella Giovanni, Carninci Piero, Fongang Bernard, Bieniek Kevin F, Frost Bess

Abstract excerpt

INTRODUCTION: Faulty DNA repair and epigenetic regulation contribute to neurodegeneration in Alzheimer's disease. Long-read sequencing enables analysis of "dark regions" that are difficult to study via traditional sequencing methodologies. METHODS: Using nanopore whole-genome DNA sequencing of post mortem brain from early- and late- stage Alzheimer's disease cases and controls, we analyzed retrotransposition,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41235755
DOI: 10.1002/alz.70852
PMCID: PMC12616516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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