Article

Recombination of repeat elements generates somatic complexity in human genomes

2020-07-02

Abstract excerpt

<h4>Summary</h4> Millions of Alu and L1 copies in our genomes contribute to evolution and genetic disorders via non-allelic homologous recombination, but the somatic extent of these rearrangements has not been systematically investigated. Here we combine short and long DNA reads sequencing of repeat elements with a new bioinformatic pipeline to show that somatic recombination of Alu and L1 elements is common in h...

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Literature Corpus work: ecccebf3-ae02-5ee2-970f-e784bd7d90fe
DOI: 10.1101/2020.07.02.163816

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