Article

Nanopore Long-Read Sequencing Unveils Genomic Disruptions in Alzheimer’s Disease

2024-02-05

Abstract excerpt

<h4>ABSTRACT</h4> Studies in laboratory models and postmortem human brain tissue from patients with Alzheimer’s disease have revealed disruption of basic cellular processes such as DNA repair and epigenetic control as drivers of neurodegeneration. While genomic alterations in regions of the genome that are rich in repetitive sequences, often termed “dark regions,” are difficult to resolve using traditional sequen...

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Literature Corpus work: 0cbfc45e-cdd9-5060-a558-ab4f49c24170
DOI: 10.1101/2024.02.01.578450

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